Cover image for "The Philanthropic Strategies of the Bill & Melinda Gates Foundation and the Chan Zuckerberg Initiative" - Get Mentors Blog

The Philanthropic Strategies of the Bill & Melinda Gates Foundation and the Chan Zuckerberg Initiative

Jesse Krim - Founder & CEO profile picture

Jesse Krim

5 min

Share

The Philanthropic Strategies of the Bill & Melinda Gates Foundation and the Chan Zuckerberg Initiative

Two tech billionaires took opposite paths to change the world. One fixed urgent crises. The other bet on breakthrough science.

Both made massive impact. But they used completely different strategies.

Here's the simple framework they both follow.

The Impact-First Model

This model combines two proven approaches. Gates' crisis response strategy and Chan-Zuckerberg's systems change method.

You can use either approach. Or combine them. Both work for any budget.

What Gates Does: Fix Urgent Problems Fast

Gates built the world's biggest private foundation on one idea. Find urgent problems with known solutions. Then scale those solutions everywhere.

The Gates Foundation spent $60 billion since 2000. Their vaccine programs saved 13.5 million lives in poor countries. That's real impact you can measure.

Gates picks fights he can win quickly. Malaria nets save lives in months. Polio vaccines work in weeks. You see results fast.

His method works in three steps:

  1. Find urgent problems
  2. Scale existing solutions
  3. Measure everything

What Chan-Zuckerberg Does: Create Breakthrough Solutions

Priscilla Chan and Mark Zuckerberg chose a different path. They tackle problems without clear solutions yet.

The Chan Zuckerberg Initiative pledged $45 billion to advance human potential. They fund basic science research and education technology. Their timeline spans decades.

They bet on breakthrough innovations. They funded single-cell research tools that could change medicine. Their education platform reaches 20 million students.

Their method also works in three steps:

  1. Find system-wide problems
  2. Create new solutions from scratch
  3. Accept longer timelines for bigger wins

Your 3-Step Impact-First Plan

Step 1: Pick Your Impact Style (15 minutes)

Choose crisis response OR systems change. Don't try both at once.

Crisis response works for:

  • Hunger in your community
  • Homeless shelters
  • Emergency relief

Systems change works for:

  • Education gaps
  • Climate issues
  • Long-term inequality

Write down: "I will focus on _____ problems using the _____ approach."

Step 2: Use the 10x Impact Test (5 minutes per idea)

Ask this question about every idea: "Will this help 10 times more people than what I'm doing now?"

If yes, pursue it. If no, drop it.

Gates used this for vaccine distribution. One decision affects millions of people worldwide.

Chan-Zuckerberg uses this for research tools. One breakthrough helps thousands of scientists.

Step 3: Track One Number (10 minutes weekly)

Pick one number that proves your impact. Check it every week.

Gates tracks: Lives saved per dollar spent Chan-Zuckerberg tracks: Scientific breakthroughs their funding created

Your number might be: People helped, problems solved, or systems changed.

What Results to Expect

Week 1: You have clear focus on immediate problems or long-term systems Month 1: You see your first measurable impact using your chosen approach
Month 3: You refine your strategy based on what works best

The key difference matters. Gates goes for speed and scale. Chan-Zuckerberg goes for depth and disruption.

Both approaches work. Pick the one that fits your personality.

Why This Works for Everyone

You don't need billions to use this model. It scales down perfectly.

A teacher can use crisis response for struggling students. Or systems change for better curriculum.

A business owner can fix immediate customer problems. Or build new solutions for future needs.

The framework forces one crucial choice. Do you want fast results or breakthrough impact?

Both are valuable. But mixing them creates confusion and waste.

Gates Proves Crisis Response Works

His foundation cut child deaths by 60% in target countries. He picked clear problems with proven solutions. Then he scaled them massively.

Gates focuses on immediate impact. Bed nets prevent malaria deaths within months. Clean water stops diseases within weeks.

Chan-Zuckerberg Proves Systems Change Works

They fund research that could eliminate genetic diseases. The timeline is unclear but the potential is unlimited.

They focus on breakthrough impact. Their education technology could change how millions learn. Their science tools could speed up medical discoveries.

Like how Tom Brady maintained his edge for decades, consistency beats trying everything at once.

Start Your Impact Today

Choose your approach right now. Write down three problems you want to solve.

Label each one: Crisis response or systems change?

Pick the approach that matches your strengths:

  • Love quick wins and clear numbers? Follow Gates.
  • Enjoy big challenges and long-term thinking? Follow Chan-Zuckerberg.

Both paths create real impact. The wrong path is trying both at once.

Similar to how Joe Rogan built his audience from scratch, focus wins over scattered effort.

Your Next Action

Open your phone right now. Set a weekly reminder called "Impact Check."

Every week, look at your one number. Ask: "Am I helping more people this week than last week?"

If yes, keep going. If no, change your approach.

Your impact starts with your next decision. Make it count.

Ready to turn your ideas into world-changing impact? Get Mentors connects you with proven leaders who built successful social organizations. Learn directly from people who created lasting change.

Quick Info

PublishedOctober 1, 2025
Reading Time5 min read minutes
CategorySuccess Stories